Fesoterodine vs tolterodine in men and women with OAB

Ginsberg D, Schneider T, Kelleher C, Van Kerrebroeck P, Swift S, Creanga D and Martire DL. Efficacy of fesoterodine compared with extended-release tolterodine in men and women with overactive bladder. BJUI 2013; 112: 373–385. doi: 10.1111/bju.12174.

So our study looked at pool data from two separate 12-week identical studies that were evaluating ethicacy and patient to the overactive bladder it standard eligibility requirements for patients though grafton bladder he had to have symptoms of overactive bladder for a minute about three months we had a total of four thousand one hundred and twenty nine patients who

Are randomized and 4108 patients received treatment the majority of whom were women and they were randomized to three different arms in a two to two to one ratio which was told harry dean four milligrams told thirteen extended-release four milligrams as i’m tara dean eight milligrams or placebo now the results were a combination of voiding diaries and a variety of

Quality of life questionnaires with the primary end point being change in urgency urinary incontinence at 12 weeks results were broken down by gender we believe this is the first study to compare anti muscarinic efficacy in women and men in the same study now when you look at our results in the female patients at 12 weeks we saw a significantly greater improvement

With 8 milligrams of facet arity compared to 4 milligrams of totality and extensive release and placebo in patients in regards to your urgency urinary incontinence episodes urinary frequency urgency episodes diary dry weight and quality of life questionnaires including patient perception of bladder condition urgency perception scale and oab q in the male patients

Interesting we did not see a difference in terms of uui episodes between any of the treatment groups however we did see a greater improvement between both placebo and told tarrying four milligrams in the harry dean eight million group for both severe urgency and the symptom bother domain of the oh abq we also saw greater improvements compared to just placebo alone

Than regards to voting frequency urgency severe urgency pp b c and o abq in regards to adverse events not surprisingly the most frequent adverse events were dry mouth and constipation but a more so with vegetarian followed by caldera t and then followed by kosovo so what did we learn from this trial for the female patients in this study these findings are consistent

With several other studies that if shown pheasant hair eighteen eight milligrams is superior to told harry dean extended release four milligrams it is especially nice to see this for urgency or urinary incontinence and the dry rate which shows that this medication is clearly impacting one of the most if not the most bothersome symptom related to overactive bladder

In regards to the male patients we did not see the same level of effect with these men in regards to your urinary incontinence that we did see creative improvements in regards to urgency and i suspect this lack of improvement may be related to lack of power with smaller numbers and men enrolled in the study thanks for tuning in have a good afternoon bye

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Fesoterodine vs tolterodine in men and women with OAB By BJUI